Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wavelet	13_GS	1.39e-05	1.28e-05	7.35e-11	2.72e-09
13_GS	Wavelet	2.90e-02	3.28e-02	1.25e-04	6.26e-09



Evaluating how well Wavelet genes are linked to 13_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet	13_GS	0.95	3.72	5.95	3.27	4.82
13_GS	Wavelet	0.72	0.94	1.53	0.89	5.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet	13_GS	0.01	8.02	39.23	13.57	10.82
13_GS	Wavelet	0.01	8.45	8.26	9.63	14.21

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wavelet	75	75	
13_GS	14	14