Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wavelet Exclusive	25_GS	3.95e-02	1.91e-01	2.29e-05	2.30e-03
25_GS Exclusive	Wavelet	3.14e-03	2.16e-02	2.46e-05	2.87e-07
Wavelet Exclusive	25_GS Exclusive	1.11e-01	1.85e-01	2.29e-04	7.40e-03
25_GS Exclusive	Wavelet Exclusive	2.31e-02	3.72e-02	3.23e-04	1.45e-06
Wavelet Exclusive	Overlap	3.80e-01	8.14e-01	8.68e-02	1.50e-01
25_GS Exclusive	Overlap	1.38e-03	1.38e-03	1.38e-03	1.53e-03
Overlap	Exclusives	1.38e-03	6.00e-09	1.46e-16	1.02e-14



Evaluating how well Wavelet genes are linked to 25_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet Exclusive	25_GS	0.70	0.88	1.33	1.19	3.61
25_GS Exclusive	Wavelet	0.70	0.71	2.06	1.19	6.18
Wavelet Exclusive	25_GS Exclusive	0.68	0.62	1.29	0.92	3.04
25_GS Exclusive	Wavelet Exclusive	0.69	0.37	1.53	0.67	6.59
Wavelet Exclusive	Overlap	0.84	1.52	0.54	1.18	2.05
25_GS Exclusive	Overlap	1.00	3.32	2.34	2.91	2.68
Overlap	Exclusives	0.76	1.77	5.05	1.71	8.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet Exclusive	25_GS	0.00	2.92	4.30	1.40	3.60
25_GS Exclusive	Wavelet	0.01	4.80	7.15	8.82	13.87
Wavelet Exclusive	25_GS Exclusive	0.00	2.03	4.48	0.87	5.22
25_GS Exclusive	Wavelet Exclusive	0.01	1.97	3.34	4.29	3.03
Wavelet Exclusive	Overlap	0.00	1.56	1.12	6.34	5.42
25_GS Exclusive	Overlap	0.05	214.40	73.88	138.40	10.38
Overlap	Exclusives	0.03	20.18	39.78	15.51	51.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wavelet Exclusive	72	72	
25_GS Exclusive	22	21	HLA -DRB1
Overlap	3	3