Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML2	13_GS	3.29e-01	5.00e-02	3.98e-02	1.99e-04
13_GS	EAML2	5.96e-01	9.95e-02	6.67e-04	7.79e-02



Evaluating how well EAML2 genes are linked to 13_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML2	13_GS	0.81	1.40	3.26	2.17	4.03
13_GS	EAML2	0.61	2.78	2.42	2.19	2.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML2	13_GS	0.00	0.60	1.07	1.98	0.10
13_GS	EAML2	0.00	3.21	0.95	2.39	2.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML2	34	34	
13_GS	14	14