Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML2 Exclusive	25_GS	5.98e-01	9.37e-01	7.55e-01	9.84e-02
25_GS Exclusive	EAML2	9.70e-01	4.12e-01	2.94e-01	3.69e-01
EAML2 Exclusive	25_GS Exclusive	6.05e-01	7.93e-01	8.98e-01	1.69e-01
25_GS Exclusive	EAML2 Exclusive	9.58e-01	4.18e-01	2.40e-01	5.61e-01
EAML2 Exclusive	Overlap	7.54e-01	9.92e-02	3.35e-01	1.66e-01
25_GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	2.37e-02	1.94e-04	4.50e-23	5.00e-06



Evaluating how well EAML2 genes are linked to 25_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML2 Exclusive	25_GS	0.60	-0.54	-0.08	-0.23	1.70
25_GS Exclusive	EAML2	0.55	0.99	0.79	0.88	1.05
EAML2 Exclusive	25_GS Exclusive	0.58	-0.52	-0.16	-0.13	1.27
25_GS Exclusive	EAML2 Exclusive	0.53	0.98	0.59	0.64	0.64
EAML2 Exclusive	Overlap	0.90	0.41	-218299805863219.50	0.70	1.37
25_GS Exclusive	Overlap	1.00	1.36	111424462830387.00	1.79	1.54
Overlap	Exclusives	0.71	inf	5.65	2.68	6.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML2 Exclusive	25_GS	0.00	-0.33	-0.43	-0.37	0.23
25_GS Exclusive	EAML2	0.00	1.21	-0.07	0.53	0.07
EAML2 Exclusive	25_GS Exclusive	0.00	-0.31	-0.53	-0.32	-0.02
25_GS Exclusive	EAML2 Exclusive	0.00	0.06	-0.23	-0.21	-0.20
EAML2 Exclusive	Overlap	0.00	-0.25	-inf	-0.04	0.17
25_GS Exclusive	Overlap	0.02	14.13	32920936630948200.00	78.99	48.77
Overlap	Exclusives	0.01	inf	20.55	12.37	19.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML2 Exclusive	33	33	
25_GS Exclusive	24	23	HLA -DRB1
Overlap	1	1