Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
String	GS_25	4.30e-01	2.17e-01	2.31e-01	7.65e-02
GS_25	String	1.84e-04	3.49e-03	2.55e-02	1.64e-03



Evaluating how well String genes are linked to GS_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
String	GS_25	0.66	0.73	1.93	0.80	2.59
GS_25	String	0.45	1.37	-0.26	0.29	-1.93

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
String	GS_25	0.00	0.65	1.90	0.36	1.69
GS_25	String	0.01	0.99	0.10	0.21	-0.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
String	128	128	
GS_25	25	24	HLA -DRB1