Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
String	GS_25	3.87e-04	6.37e-01	2.48e-03	6.37e-01
GS_25	String	5.11e-14	5.93e-06	1.45e-03	8.96e-02



Evaluating how well String genes are linked to GS_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
String	GS_25	0.56	-1.60	-1.07	-0.98	1.02
GS_25	String	0.48	-1.85	-6.81	-1.53	-1.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
String	GS_25	0.00	-0.86	-0.87	-0.73	-0.14
GS_25	String	0.01	-0.54	-4.19	-0.87	-1.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
String	239	237	MUC2;MUC19
GS_25	25	24	HLA -DRB1