Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
String-Reactome	13_GS	2.19e-02	1.10e-01	8.25e-03	1.76e-03
13_GS	String-Reactome	2.99e-02	2.32e-01	5.08e-03	3.62e-02



Evaluating how well String-Reactome genes are linked to 13_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
String-Reactome	13_GS	0.72	0.64	1.85	0.58	2.68
13_GS	String-Reactome	0.54	0.76	-0.85	-0.06	0.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
String-Reactome	13_GS	0.00	-0.00	0.24	-0.08	0.42
13_GS	String-Reactome	0.00	-0.08	-0.88	-0.40	-0.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
String-Reactome	16	16	
13_GS	14	14