Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
String-Reactome	25_GS	2.52e-03	6.12e-01	1.09e-02	1.83e-02
25_GS	String-Reactome	7.08e-01	4.55e-01	3.08e-02	2.42e-02



Evaluating how well String-Reactome genes are linked to 25_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
String-Reactome	25_GS	0.64	-0.28	0.72	0.19	2.11
25_GS	String-Reactome	0.59	0.51	0.29	0.21	1.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
String-Reactome	25_GS	0.00	-0.45	-0.12	-0.19	0.76
25_GS	String-Reactome	0.00	-0.10	-0.44	-0.32	-0.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
String-Reactome	16	16	
25_GS	25	24	HLA -DRB1