Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OldEAML	EAW	3.71e-01	3.34e-01	9.17e-01	1.05e-04
EAW	OldEAML	6.11e-01	8.60e-01	2.20e-02	8.20e-01



Evaluating how well OldEAML genes are linked to EAW genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OldEAML	EAW	0.67	1.22	1.16	0.79	3.98
EAW	OldEAML	0.49	0.33	0.69	0.06	-0.41

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OldEAML	EAW	0.00	0.45	0.32	-0.06	2.40
EAW	OldEAML	0.01	0.66	0.19	0.29	-0.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OldEAML	98	98	
EAW	41	41