Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI Exclusive	OldEAML	4.51e-01	5.43e-01	4.63e-01	5.99e-01
OldEAML Exclusive	EPI	2.26e-01	1.24e-01	2.37e-01	3.72e-01
EPI Exclusive	OldEAML Exclusive	5.03e-01	5.35e-01	4.67e-01	6.16e-01
OldEAML Exclusive	EPI Exclusive	1.02e-01	5.03e-02	1.71e-01	3.93e-01
EPI Exclusive	Overlap	5.93e-01	6.47e-01	5.40e-01	5.93e-01
OldEAML Exclusive	Overlap	6.74e-01	3.51e-01	5.14e-01	8.72e-01
Overlap	Exclusives	2.80e-01	5.64e-01	3.82e-11	4.30e-01



Evaluating how well EPI genes are linked to OldEAML genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI Exclusive	OldEAML	0.50	0.96	0.95	0.74	0.28
OldEAML Exclusive	EPI	0.52	0.84	0.85	1.18	0.27
EPI Exclusive	OldEAML Exclusive	0.50	1.01	0.83	0.85	-0.08
OldEAML Exclusive	EPI Exclusive	0.52	1.31	1.13	1.32	0.28
EPI Exclusive	Overlap	0.52	-0.24	-0.37	-0.32	0.16
OldEAML Exclusive	Overlap	0.44	-1.06	-1.45	-1.28	-0.30
Overlap	Exclusives	0.48	-0.94	0.49	0.75	-0.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI Exclusive	OldEAML	0.01	0.85	0.68	0.22	0.43
OldEAML Exclusive	EPI	0.00	-0.26	-0.31	-0.11	-0.31
EPI Exclusive	OldEAML Exclusive	0.01	0.69	0.56	0.75	0.01
OldEAML Exclusive	EPI Exclusive	0.00	-0.11	0.07	-0.12	-0.27
EPI Exclusive	Overlap	0.00	0.95	0.69	0.29	-0.04
OldEAML Exclusive	Overlap	0.00	-0.44	-0.61	-0.62	-0.37
Overlap	Exclusives	0.01	-0.48	-0.11	0.11	-0.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI Exclusive	32	31	AC003002.1
OldEAML Exclusive	96	96	
Overlap	2	2