Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI Exclusive	NewEAML	8.01e-01	9.83e-01	5.05e-01	5.45e-01
NewEAML Exclusive	EPI	9.61e-01	9.40e-01	9.26e-01	4.76e-01
EPI Exclusive	NewEAML Exclusive	8.17e-01	9.03e-01	5.49e-01	6.48e-01
NewEAML Exclusive	EPI Exclusive	6.98e-01	6.29e-01	7.72e-01	2.88e-01
EPI Exclusive	Overlap	9.46e-01	8.09e-01	6.68e-01	8.65e-01
NewEAML Exclusive	Overlap	5.92e-01	4.54e-01	5.53e-01	5.24e-01
Overlap	Exclusives	8.23e-01	1.89e-01	4.98e-01	3.63e-01



Evaluating how well EPI genes are linked to NewEAML genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI Exclusive	NewEAML	0.51	0.03	-0.01	0.20	0.59
NewEAML Exclusive	EPI	0.48	-0.02	0.24	0.41	-0.38
EPI Exclusive	NewEAML Exclusive	0.51	0.02	-0.29	0.20	0.54
NewEAML Exclusive	EPI Exclusive	0.46	-0.30	-0.22	0.24	-0.65
EPI Exclusive	Overlap	0.51	0.20	0.91	0.10	-0.02
NewEAML Exclusive	Overlap	0.52	0.32	0.66	0.36	0.36
Overlap	Exclusives	0.52	1.34	1.17	0.94	0.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI Exclusive	NewEAML	0.00	0.02	-0.18	0.05	0.02
NewEAML Exclusive	EPI	0.00	-0.17	0.04	-0.05	-0.17
EPI Exclusive	NewEAML Exclusive	0.00	0.08	-0.28	0.21	0.49
NewEAML Exclusive	EPI Exclusive	0.00	0.03	0.33	0.22	-0.10
EPI Exclusive	Overlap	0.00	-0.51	0.04	-0.34	-0.20
NewEAML Exclusive	Overlap	0.00	-0.39	-0.36	-0.41	-0.33
Overlap	Exclusives	0.01	0.23	0.06	-0.09	-0.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI Exclusive	22	21	AC003002.1
NewEAML Exclusive	78	78	
Overlap	12	12