Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
v4_Consensus2 Exclusive	BMI	2.66e-03	1.94e-03	5.46e-05	1.01e-05
BMI Exclusive	v4_Consensus2	9.28e-03	2.42e-03	5.93e-04	2.59e-06
v4_Consensus2 Exclusive	BMI Exclusive	5.08e-03	1.69e-03	3.11e-05	4.36e-05
BMI Exclusive	v4_Consensus2 Exclusive	1.48e-02	2.79e-03	1.27e-03	4.95e-06
v4_Consensus2 Exclusive	Overlap	1.12e-01	9.92e-02	1.05e-01	1.33e-01
BMI Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	2.26e-04	6.39e-04	2.29e-27	9.96e-10



Evaluating how well v4_Consensus2 genes are linked to BMI genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v4_Consensus2 Exclusive	BMI	0.83	1.95	3.57	2.06	4.26
BMI Exclusive	v4_Consensus2	0.64	2.21	3.86	2.01	6.98
v4_Consensus2 Exclusive	BMI Exclusive	0.82	1.97	3.46	2.26	4.47
BMI Exclusive	v4_Consensus2 Exclusive	0.64	2.29	3.37	1.98	6.28
v4_Consensus2 Exclusive	Overlap	0.98	0.74	1.61	0.88	1.56
BMI Exclusive	Overlap	1.00	1.54	3.56	1.76	1.83
Overlap	Exclusives	0.66	1.95	4.27	1.74	6.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v4_Consensus2 Exclusive	BMI	0.00	2.64	4.96	3.19	7.06
BMI Exclusive	v4_Consensus2	0.01	3.71	5.53	4.42	9.35
v4_Consensus2 Exclusive	BMI Exclusive	0.00	2.41	4.58	3.55	2.84
BMI Exclusive	v4_Consensus2 Exclusive	0.01	3.24	4.50	3.22	5.86
v4_Consensus2 Exclusive	Overlap	0.00	0.27	7.76	0.49	-0.00
BMI Exclusive	Overlap	0.04	89.05	545.45	168.25	54.88
Overlap	Exclusives	0.02	6.17	6.20	4.01	12.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
v4_Consensus2 Exclusive	163	162	GCSAML-AS1
BMI Exclusive	16	16	
Overlap	1	1