Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
v4_Consensus2 Exclusive	T2D_GWAS	4.95e-01	1.03e-01	1.41e-05	5.17e-09
T2D_GWAS Exclusive	v4_Consensus2	3.42e-01	1.97e-01	2.73e-07	4.39e-07
v4_Consensus2 Exclusive	T2D_GWAS Exclusive	3.77e-01	1.90e-01	1.98e-05	2.04e-08
T2D_GWAS Exclusive	v4_Consensus2 Exclusive	3.41e-01	7.02e-01	6.20e-05	4.94e-06
v4_Consensus2 Exclusive	Overlap	7.98e-01	7.98e-01	3.68e-01	2.99e-01
T2D_GWAS Exclusive	Overlap	3.11e-03	3.71e-03	2.44e-04	2.42e-03
Overlap	Exclusives	4.69e-08	2.20e-07	4.95e-21	1.32e-25



Evaluating how well v4_Consensus2 genes are linked to T2D_GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v4_Consensus2 Exclusive	T2D_GWAS	0.63	1.18	1.59	1.86	6.17
T2D_GWAS Exclusive	v4_Consensus2	0.63	0.77	2.09	2.28	5.83
v4_Consensus2 Exclusive	T2D_GWAS Exclusive	0.63	1.53	1.69	1.92	5.86
T2D_GWAS Exclusive	v4_Consensus2 Exclusive	0.61	-0.15	1.32	1.31	5.45
v4_Consensus2 Exclusive	Overlap	0.59	-0.22	0.06	0.53	1.44
T2D_GWAS Exclusive	Overlap	0.84	5.03	3.59	4.24	3.69
Overlap	Exclusives	0.69	3.68	9.48	4.72	13.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v4_Consensus2 Exclusive	T2D_GWAS	0.01	-0.37	0.54	1.77	4.30
T2D_GWAS Exclusive	v4_Consensus2	0.02	9.11	8.29	11.97	10.15
v4_Consensus2 Exclusive	T2D_GWAS Exclusive	0.01	-0.02	0.78	1.61	5.79
T2D_GWAS Exclusive	v4_Consensus2 Exclusive	0.01	1.30	1.16	2.21	3.69
v4_Consensus2 Exclusive	Overlap	0.00	-0.58	-0.63	-0.16	-0.10
T2D_GWAS Exclusive	Overlap	0.10	880.02	314.01	443.48	8.81
Overlap	Exclusives	0.05	10.85	29.08	14.80	32.82

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
v4_Consensus2 Exclusive	155	154	GCSAML-AS1
T2D_GWAS Exclusive	197	188	ZNF664-FAM101A;LINC00885;LOC440028;LOC157273;TMEM110-MUSTN1;LOC101928994;LOC101928448;LINC00261;SERHL
Overlap	9	9