Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Male_Consensus Exclusive	GWAS	6.69e-01	9.52e-01	1.04e-03	9.77e-05
GWAS Exclusive	Male_Consensus	4.00e-01	7.81e-01	1.19e-04	3.90e-05
Male_Consensus Exclusive	GWAS Exclusive	4.52e-01	9.29e-01	1.80e-03	1.28e-04
GWAS Exclusive	Male_Consensus Exclusive	1.94e-01	9.41e-01	9.13e-04	5.29e-04
Male_Consensus Exclusive	Overlap	8.14e-01	9.37e-01	4.04e-01	1.61e-01
GWAS Exclusive	Overlap	4.19e-02	2.63e-02	5.49e-03	2.56e-03
Overlap	Exclusives	1.11e-08	6.10e-09	2.18e-44	5.40e-24



Evaluating how well Male_Consensus genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Male_Consensus Exclusive	GWAS	0.60	-0.07	-0.25	0.74	5.37
GWAS Exclusive	Male_Consensus	0.60	-0.22	0.69	1.15	4.69
Male_Consensus Exclusive	GWAS Exclusive	0.60	-0.41	-0.30	0.64	4.33
GWAS Exclusive	Male_Consensus Exclusive	0.58	-0.66	-0.26	0.68	3.37
Male_Consensus Exclusive	Overlap	0.70	1.38	0.29	1.22	2.40
GWAS Exclusive	Overlap	0.86	3.45	3.63	3.01	3.86
Overlap	Exclusives	0.68	7.25	7.99	4.58	11.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Male_Consensus Exclusive	GWAS	0.01	-0.50	-0.99	0.75	3.08
GWAS Exclusive	Male_Consensus	0.02	4.91	7.22	6.28	8.17
Male_Consensus Exclusive	GWAS Exclusive	0.01	-0.74	-0.97	0.51	3.00
GWAS Exclusive	Male_Consensus Exclusive	0.01	-0.74	-0.47	0.37	1.22
Male_Consensus Exclusive	Overlap	0.00	-0.10	1.25	2.22	1.60
GWAS Exclusive	Overlap	0.10	86.55	216.11	220.82	498.30
Overlap	Exclusives	0.05	19.75	27.78	14.70	28.45

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Male_Consensus Exclusive	172	171	GCSAML-AS1
GWAS Exclusive	198	189	LINC00885;LOC157273;TMEM110-MUSTN1;LINC00261;ZNF664-FAM101A;LOC101928994;LOC440028;SERHL;LOC101928448
Overlap	8	8