Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MS_Consensus3	Meta	3.78e-10	2.23e-06	3.16e-11	5.55e-11
Meta	MS_Consensus3	1.58e-03	3.70e-03	2.53e-04	2.48e-03



Evaluating how well MS_Consensus3 genes are linked to Meta genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_Consensus3	Meta	0.90	2.25	6.28	2.26	7.51
Meta	MS_Consensus3	0.74	1.09	2.68	2.05	2.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_Consensus3	Meta	0.02	5.34	20.29	12.52	13.33
Meta	MS_Consensus3	0.01	6.23	9.56	13.92	6.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MS_Consensus3	18	18	
Meta	26	26