Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MS_Consensus3	All_IMSGC	2.77e-03	2.86e-03	5.60e-19	1.33e-09
All_IMSGC	MS_Consensus3	7.47e-03	1.76e-02	6.14e-03	1.89e-04



Evaluating how well MS_Consensus3 genes are linked to All_IMSGC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_Consensus3	All_IMSGC	0.60	2.63	5.03	2.34	7.39
All_IMSGC	MS_Consensus3	0.77	1.53	2.08	1.72	4.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_Consensus3	All_IMSGC	0.04	4.24	7.38	4.28	9.23
All_IMSGC	MS_Consensus3	0.00	4.83	0.07	6.15	9.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MS_Consensus3	18	18	
All_IMSGC	559	530	MIR21;RP11-345J4.5;RPL34-AS1;ST13P4;LOC285626;CTB-50L17.10;PVT1;1-Sep;SSTR5-AS1;MIR1208;JAZF1-AS1;1-Mar;ZEB1-AS1;LOC100506746;MIR548AN;PCAT1;LOC152225;LOC285740;9-Mar;U47924.1;LOC646626;MIR4778;LINC00977;MYO15B;GATA3-AS1;LINC01100;SNORA66;MIR4262;LINC01082