Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MS_EPI Exclusive	Exonic_IMSGC	2.39e-02	2.15e-03	7.91e-02	1.09e-04
Exonic_IMSGC Exclusive	MS_EPI	1.19e-01	3.36e-01	3.14e-02	2.76e-01
MS_EPI Exclusive	Exonic_IMSGC Exclusive	2.40e-02	1.03e-03	1.39e-01	1.43e-04
Exonic_IMSGC Exclusive	MS_EPI Exclusive	1.40e-01	3.39e-01	2.43e-02	3.36e-01
MS_EPI Exclusive	Overlap	2.04e-01	7.05e-01	1.84e-01	7.75e-01
Exonic_IMSGC Exclusive	Overlap	5.21e-01	1.42e-01	2.49e-01	6.55e-02
Overlap	Exclusives	6.48e-05	1.30e-01	1.51e-02	7.02e-01



Evaluating how well MS_EPI genes are linked to Exonic_IMSGC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_EPI Exclusive	Exonic_IMSGC	0.57	3.40	3.40	2.78	3.99
Exonic_IMSGC Exclusive	MS_EPI	0.48	2.36	2.25	2.14	-1.07
MS_EPI Exclusive	Exonic_IMSGC Exclusive	0.57	3.16	3.52	2.86	4.48
Exonic_IMSGC Exclusive	MS_EPI Exclusive	0.48	2.34	1.93	1.87	-1.15
MS_EPI Exclusive	Overlap	0.48	-1.07	-0.27	-0.68	-0.10
Exonic_IMSGC Exclusive	Overlap	0.73	1.95	2.73	1.95	2.04
Overlap	Exclusives	0.51	0.69	1.43	0.72	0.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_EPI Exclusive	Exonic_IMSGC	0.02	2.69	1.58	2.39	1.80
Exonic_IMSGC Exclusive	MS_EPI	0.02	3.82	3.55	3.00	-0.41
MS_EPI Exclusive	Exonic_IMSGC Exclusive	0.02	2.21	1.97	2.19	2.98
Exonic_IMSGC Exclusive	MS_EPI Exclusive	0.02	2.98	3.18	2.53	-0.61
MS_EPI Exclusive	Overlap	0.00	-0.76	-0.44	-0.69	-0.54
Exonic_IMSGC Exclusive	Overlap	0.00	4.30	18.67	11.50	5.33
Overlap	Exclusives	0.03	1.09	1.74	1.12	1.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MS_EPI Exclusive	342	337	RFPL2;AL669918.1;AC131097.2;CCDC169-SOHLH2;AC019117.2
Exonic_IMSGC Exclusive	299	298	1-Sep
Overlap	5	5