Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MS_EAW Exclusive	Meta	3.53e-06	8.98e-06	2.80e-14	4.45e-12
Meta Exclusive	MS_EAW	2.09e-09	1.30e-08	1.65e-23	1.45e-18
MS_EAW Exclusive	Meta Exclusive	1.63e-05	8.49e-05	2.41e-12	7.83e-10
Meta Exclusive	MS_EAW Exclusive	9.29e-09	2.16e-07	6.02e-22	5.75e-18
MS_EAW Exclusive	Overlap	4.29e-02	3.16e-02	7.79e-04	9.24e-04
Meta Exclusive	Overlap	1.69e-04	1.69e-04	1.69e-04	2.04e-04
Overlap	Exclusives	2.48e-07	2.63e-09	6.76e-41	8.96e-35



Evaluating how well MS_EAW genes are linked to Meta genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_EAW Exclusive	Meta	0.91	2.58	5.02	2.39	7.64
Meta Exclusive	MS_EAW	0.73	-0.32	5.05	2.43	13.25
MS_EAW Exclusive	Meta Exclusive	0.90	2.74	4.60	2.99	6.42
Meta Exclusive	MS_EAW Exclusive	0.72	-0.53	4.09	2.06	10.81
MS_EAW Exclusive	Overlap	0.97	2.04	2.30	1.75	3.06
Meta Exclusive	Overlap	1.00	1.91	4.15	2.36	3.52
Overlap	Exclusives	0.76	1.13	6.10	1.31	12.38

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_EAW Exclusive	Meta	0.02	3.63	5.09	5.43	50.36
Meta Exclusive	MS_EAW	0.03	1.91	9.32	9.76	22.36
MS_EAW Exclusive	Meta Exclusive	0.01	3.59	6.42	6.60	26.49
Meta Exclusive	MS_EAW Exclusive	0.03	0.81	6.23	6.76	20.91
MS_EAW Exclusive	Overlap	0.02	4.37	16.46	9.60	41.13
Meta Exclusive	Overlap	0.03	9.86	75.11	39.42	24.08
Overlap	Exclusives	0.04	6.08	13.37	4.13	30.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MS_EAW Exclusive	194	194	
Meta Exclusive	22	22	
Overlap	4	4