Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MS_EAML Exclusive	Meta	3.49e-04	6.30e-04	3.61e-03	1.11e-06
Meta Exclusive	MS_EAML	9.06e-04	1.18e-01	6.77e-03	2.82e-01
MS_EAML Exclusive	Meta Exclusive	1.84e-04	3.69e-04	4.37e-03	7.47e-07
Meta Exclusive	MS_EAML Exclusive	9.98e-04	1.35e-01	1.19e-02	1.96e-01
MS_EAML Exclusive	Overlap	8.11e-01	8.29e-01	6.73e-01	3.51e-01
Meta Exclusive	Overlap	9.92e-02	1.57e-01	9.92e-02	1.05e-01
Overlap	Exclusives	3.34e-02	4.89e-02	1.62e-14	1.69e-02



Evaluating how well MS_EAML genes are linked to Meta genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_EAML Exclusive	Meta	0.84	2.23	5.11	1.98	5.80
Meta Exclusive	MS_EAML	0.51	1.62	2.00	1.60	0.43
MS_EAML Exclusive	Meta Exclusive	0.85	2.17	5.44	1.98	6.04
Meta Exclusive	MS_EAML Exclusive	0.50	2.12	1.96	1.43	0.06
MS_EAML Exclusive	Overlap	0.74	0.24	0.46	0.23	0.88
Meta Exclusive	Overlap	0.99	1.23	1.51	2.23	1.68
Overlap	Exclusives	0.53	1.27	2.03	0.86	1.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_EAML Exclusive	Meta	0.01	7.13	17.29	3.65	13.96
Meta Exclusive	MS_EAML	0.01	3.53	4.89	2.51	2.04
MS_EAML Exclusive	Meta Exclusive	0.01	7.06	23.33	3.56	20.85
Meta Exclusive	MS_EAML Exclusive	0.01	4.13	5.05	2.09	2.54
MS_EAML Exclusive	Overlap	0.00	-0.27	-0.24	-0.26	-0.09
Meta Exclusive	Overlap	0.00	0.72	2.57	13.66	6.81
Overlap	Exclusives	0.01	1.70	5.35	1.59	4.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MS_EAML Exclusive	145	143	CCDC169-SOHLH2;AL669918.1
Meta Exclusive	25	25	
Overlap	1	1