Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MS_EAML Exclusive	All_IMSGC	1.36e-02	2.04e-04	3.20e-01	1.31e-07
All_IMSGC Exclusive	MS_EAML	2.12e-01	2.33e-01	1.33e-02	5.34e-01
MS_EAML Exclusive	All_IMSGC Exclusive	1.41e-02	4.41e-04	2.88e-01	5.32e-08
All_IMSGC Exclusive	MS_EAML Exclusive	1.89e-01	1.94e-01	1.49e-02	4.89e-01
MS_EAML Exclusive	Overlap	3.06e-01	7.54e-01	6.93e-01	7.14e-01
All_IMSGC Exclusive	Overlap	8.11e-01	6.93e-01	6.73e-01	7.73e-01
Overlap	Exclusives	3.60e-01	1.78e-01	2.30e-02	4.02e-04



Evaluating how well MS_EAML genes are linked to All_IMSGC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_EAML Exclusive	All_IMSGC	0.58	2.91	5.32	2.46	6.37
All_IMSGC Exclusive	MS_EAML	0.51	3.59	2.22	2.78	0.25
MS_EAML Exclusive	All_IMSGC Exclusive	0.58	3.09	4.91	2.53	7.50
All_IMSGC Exclusive	MS_EAML Exclusive	0.51	5.05	2.65	2.63	0.32
MS_EAML Exclusive	Overlap	0.54	0.82	0.09	0.40	0.23
All_IMSGC Exclusive	Overlap	0.47	0.19	0.04	0.25	0.02
Overlap	Exclusives	0.53	-0.01	0.64	0.05	3.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_EAML Exclusive	All_IMSGC	0.04	3.31	5.59	2.75	5.78
All_IMSGC Exclusive	MS_EAML	0.01	4.56	1.06	1.18	0.58
MS_EAML Exclusive	All_IMSGC Exclusive	0.04	3.32	5.26	2.80	7.54
All_IMSGC Exclusive	MS_EAML Exclusive	0.01	6.16	1.09	2.52	0.64
MS_EAML Exclusive	Overlap	0.00	0.09	-0.27	-0.12	-0.17
All_IMSGC Exclusive	Overlap	0.00	-0.15	-0.25	-0.19	-0.29
Overlap	Exclusives	0.04	-0.17	-0.17	-0.11	2.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MS_EAML Exclusive	145	143	AL669918.1;CCDC169-SOHLH2
All_IMSGC Exclusive	558	529	CTB-50L17.10;RPL34-AS1;1-Mar;MIR4778;1-Sep;LOC152225;SNORA66;LOC285740;ZEB1-AS1;JAZF1-AS1;SSTR5-AS1;LINC00977;GATA3-AS1;MIR1208;LOC100506746;LINC01100;PVT1;LOC646626;LINC01082;PCAT1;MYO15B;MIR21;RP11-345J4.5;ST13P4;LOC285626;MIR548AN;9-Mar;MIR4262;U47924.1
Overlap	1	1