Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MS_EAML Exclusive	Exonic_IMSGC	3.65e-02	5.12e-03	7.79e-01	1.94e-04
Exonic_IMSGC Exclusive	MS_EAML	1.62e-01	2.29e-01	4.40e-02	6.38e-01
MS_EAML Exclusive	Exonic_IMSGC Exclusive	5.00e-02	6.14e-03	5.99e-01	2.77e-04
Exonic_IMSGC Exclusive	MS_EAML Exclusive	1.42e-01	2.74e-01	4.77e-02	6.64e-01
MS_EAML Exclusive	Overlap	2.17e-01	7.73e-01	6.11e-01	5.30e-01
Exonic_IMSGC Exclusive	Overlap	5.50e-01	3.83e-01	4.35e-01	7.93e-01
Overlap	Exclusives	1.12e-01	6.73e-01	2.36e-04	4.31e-01



Evaluating how well MS_EAML genes are linked to Exonic_IMSGC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_EAML Exclusive	Exonic_IMSGC	0.57	3.06	3.28	2.64	3.99
Exonic_IMSGC Exclusive	MS_EAML	0.51	2.37	2.39	2.38	0.58
MS_EAML Exclusive	Exonic_IMSGC Exclusive	0.57	2.61	2.99	2.59	4.60
Exonic_IMSGC Exclusive	MS_EAML Exclusive	0.51	3.13	2.06	2.16	0.39
MS_EAML Exclusive	Overlap	0.54	1.15	0.10	0.47	0.37
Exonic_IMSGC Exclusive	Overlap	0.56	0.46	0.64	0.73	0.03
Overlap	Exclusives	0.50	-0.57	-0.40	-0.56	-0.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_EAML Exclusive	Exonic_IMSGC	0.02	2.42	3.54	2.76	3.05
Exonic_IMSGC Exclusive	MS_EAML	0.01	1.83	2.23	0.92	1.39
MS_EAML Exclusive	Exonic_IMSGC Exclusive	0.02	2.26	3.00	2.51	3.62
Exonic_IMSGC Exclusive	MS_EAML Exclusive	0.01	2.80	2.13	1.32	1.73
MS_EAML Exclusive	Overlap	0.00	0.45	-0.29	-0.13	-0.21
Exonic_IMSGC Exclusive	Overlap	0.00	-0.13	0.02	0.12	-0.24
Overlap	Exclusives	0.02	-0.55	-0.56	-0.49	-0.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MS_EAML Exclusive	145	143	CCDC169-SOHLH2;AL669918.1
Exonic_IMSGC Exclusive	303	302	1-Sep
Overlap	1	1