Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MS_Reactome	Meta	1.66e-06	4.53e-03	8.65e-09	1.17e-10
Meta	MS_Reactome	1.78e-05	4.01e-06	2.47e-11	1.09e-19



Evaluating how well MS_Reactome genes are linked to Meta genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_Reactome	Meta	0.89	2.71	4.56	2.38	6.21
Meta	MS_Reactome	0.72	1.51	6.56	2.58	10.48

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_Reactome	Meta	0.01	0.63	4.87	1.42	7.29
Meta	MS_Reactome	0.02	0.57	9.25	4.08	12.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MS_Reactome	189	189	
Meta	26	26