Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MS_STRING	Meta	2.40e-01	6.61e-01	1.05e-01	5.62e-04
Meta	MS_STRING	1.79e-04	8.30e-04	1.52e-03	1.61e-04



Evaluating how well MS_STRING genes are linked to Meta genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_STRING	Meta	0.73	0.54	1.27	0.26	4.20
Meta	MS_STRING	0.58	1.60	3.23	1.87	3.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_STRING	Meta	0.00	-0.48	0.14	-0.34	4.61
Meta	MS_STRING	0.01	0.94	2.34	1.34	2.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MS_STRING	175	175	
Meta	26	26