Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MS-Consensus Exclusive	Resource-Union	2.25e-02	4.74e-03	1.78e-02	2.52e-04
Resource-Union Exclusive	MS-Consensus	2.04e-02	2.36e-02	3.36e-09	5.28e-03
MS-Consensus Exclusive	Resource-Union Exclusive	6.15e-02	2.51e-02	3.33e-02	6.73e-04
Resource-Union Exclusive	MS-Consensus Exclusive	2.89e-02	3.68e-02	2.30e-08	1.41e-02
MS-Consensus Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Resource-Union Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	9.92e-06	1.95e-05	1.27e-12	3.55e-06



Evaluating how well MS-Consensus genes are linked to Resource-Union genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS-Consensus Exclusive	Resource-Union	0.89	2.32	3.54	1.78	4.24
Resource-Union Exclusive	MS-Consensus	0.57	2.54	2.88	1.57	3.17
MS-Consensus Exclusive	Resource-Union Exclusive	0.87	2.44	2.87	2.18	3.71
Resource-Union Exclusive	MS-Consensus Exclusive	0.57	2.41	2.69	1.66	2.78
MS-Consensus Exclusive	Overlap	1.00	1.40	1.91	1.38	1.79
Resource-Union Exclusive	Overlap	1.00	3.09	2.09	1.79	1.72
Overlap	Exclusives	0.62	2.95	5.72	3.65	5.93

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS-Consensus Exclusive	Resource-Union	0.01	15.53	43.66	9.37	2.77
Resource-Union Exclusive	MS-Consensus	0.01	7.29	7.22	2.90	2.90
MS-Consensus Exclusive	Resource-Union Exclusive	0.00	7.22	11.42	5.90	10.35
Resource-Union Exclusive	MS-Consensus Exclusive	0.01	5.77	2.27	4.36	5.30
MS-Consensus Exclusive	Overlap	0.02	65.76	111.09	8.43	50.97
Resource-Union Exclusive	Overlap	0.02	221.23	15.81	19.82	22.68
Overlap	Exclusives	0.02	7.78	17.84	11.07	11.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MS-Consensus Exclusive	137	135	AL669918.1;CCDC169-SOHLH2
Resource-Union Exclusive	13	8	;MIR326;MS3;CCR5AS;MS4
Overlap	1	1