Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
IMSGC_2019 Exclusive	Resource_Union	3.09e-04	5.49e-04	3.09e-04	4.25e-04
Resource_Union Exclusive	IMSGC_2019	1.18e-10	1.90e-09	8.93e-27	1.57e-14
IMSGC_2019 Exclusive	Resource_Union Exclusive	1.22e-02	1.86e-02	1.22e-02	1.35e-02
Resource_Union Exclusive	IMSGC_2019 Exclusive	1.65e-10	2.19e-08	2.39e-26	4.02e-14
IMSGC_2019 Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
Resource_Union Exclusive	Overlap	1.49e-02	1.57e-02	1.42e-02	1.35e-02
Overlap	Exclusives	8.82e-08	9.91e-13	2.32e-33	4.52e-21



Evaluating how well IMSGC_2019 genes are linked to Resource_Union genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
IMSGC_2019 Exclusive	Resource_Union	0.87	1.48	2.91	1.88	3.92
Resource_Union Exclusive	IMSGC_2019	0.68	3.11	8.38	2.09	8.89
IMSGC_2019 Exclusive	Resource_Union Exclusive	0.84	0.82	2.16	1.59	3.06
Resource_Union Exclusive	IMSGC_2019 Exclusive	0.67	3.39	7.69	2.33	10.27
IMSGC_2019 Exclusive	Overlap	0.99	1.78	1.46	1.95	2.49
Resource_Union Exclusive	Overlap	0.98	2.27	2.03	1.77	2.37
Overlap	Exclusives	0.72	1.73	10.01	3.19	12.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
IMSGC_2019 Exclusive	Resource_Union	0.02	15.73	26.43	32.37	17.03
Resource_Union Exclusive	IMSGC_2019	0.03	7.75	22.86	6.62	19.27
IMSGC_2019 Exclusive	Resource_Union Exclusive	0.01	15.79	16.27	32.38	11.89
Resource_Union Exclusive	IMSGC_2019 Exclusive	0.03	10.63	13.56	7.10	16.51
IMSGC_2019 Exclusive	Overlap	0.01	28.65	13.11	36.09	38.70
Resource_Union Exclusive	Overlap	0.00	3.64	4.78	3.96	3.79
Overlap	Exclusives	0.04	3.59	20.63	7.67	27.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
IMSGC_2019 Exclusive	263	226	LOC100129203;SATB1-AS1;LINC01108;LOC152225;LOC102467146;IL12A-AS1;LOC102723854;MIR548AN;LOC102723649;LINC00603;CASC19;LINC00824;MIR4778;LOC100129603;ZNF767P;GABARAPL3;LOC100505625;LOC285740;LOC100130476;LINC00271;LOC100506457;LOC101060498;MIR1208;LINC01082;LOC102724874;MIR4435-1HG;LOC285626;CD27-AS1;ZEB1-AS1;LINC01146;LPP-AS2;SSTR5-AS1;MIR1204;MIR100HG;PVT1;PRNCR1;LOC101929282
Resource_Union Exclusive	12	7	;MIR326;MS4;MS3;CCR5AS
Overlap	2	2