Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
IMSGC_2019 Exclusive	Resource_Intersection	1.30e-03	2.15e-03	1.30e-03	1.87e-03
Resource_Intersection Exclusive	IMSGC_2019	2.76e-10	9.74e-14	1.87e-22	2.23e-20
IMSGC_2019 Exclusive	Resource_Intersection Exclusive	1.02e-02	1.35e-02	1.02e-02	1.10e-02
Resource_Intersection Exclusive	IMSGC_2019 Exclusive	2.63e-11	9.04e-14	7.59e-21	8.88e-20
IMSGC_2019 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Resource_Intersection Exclusive	Overlap	1.18e-01	9.92e-02	1.12e-01	9.92e-02
Overlap	Exclusives	1.69e-03	2.66e-13	1.02e-45	5.90e-21



Evaluating how well IMSGC_2019 genes are linked to Resource_Intersection genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
IMSGC_2019 Exclusive	Resource_Intersection	0.92	1.97	2.91	2.30	2.92
Resource_Intersection Exclusive	IMSGC_2019	0.71	2.79	10.64	2.44	11.36
IMSGC_2019 Exclusive	Resource_Intersection Exclusive	0.90	1.90	2.48	1.85	2.93
Resource_Intersection Exclusive	IMSGC_2019 Exclusive	0.71	3.08	9.39	2.66	11.34
IMSGC_2019 Exclusive	Overlap	0.99	1.24	0.96	1.28	1.93
Resource_Intersection Exclusive	Overlap	0.97	1.54	1.13	1.41	1.84
Overlap	Exclusives	0.71	1.28	10.20	2.48	10.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
IMSGC_2019 Exclusive	Resource_Intersection	0.01	13.33	10.27	14.69	12.86
Resource_Intersection Exclusive	IMSGC_2019	0.03	6.72	22.09	5.41	29.67
IMSGC_2019 Exclusive	Resource_Intersection Exclusive	0.01	31.52	20.78	41.62	21.04
Resource_Intersection Exclusive	IMSGC_2019 Exclusive	0.03	6.92	17.77	5.96	24.68
IMSGC_2019 Exclusive	Overlap	0.00	2.74	1.15	7.71	13.28
Resource_Intersection Exclusive	Overlap	0.00	0.60	4.02	1.42	6.07
Overlap	Exclusives	0.03	1.21	18.13	3.00	18.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
IMSGC_2019 Exclusive	264	227	IL12A-AS1;LOC102724874;CASC19;MIR548AN;MIR1208;ZNF767P;ZEB1-AS1;LOC100129603;LOC102723649;LOC100129203;LOC152225;LINC01082;LOC100506457;MIR4778;LOC102723854;LINC01108;LINC01146;MIR4435-1HG;LOC100130476;PRNCR1;LOC102467146;SSTR5-AS1;LOC101929282;LPP-AS2;LOC101060498;LINC00271;LINC00603;LOC285626;PVT1;GABARAPL3;LOC285740;MIR100HG;SATB1-AS1;LOC100505625;LINC00824;CD27-AS1;MIR1204
Resource_Intersection Exclusive	4	4	
Overlap	1	1