Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wavelet77	Juan GS	6.73e-01	4.81e-01	4.43e-04	4.33e-03
Juan GS	Wavelet77	2.14e-03	5.33e-01	1.94e-07	2.79e-12



Evaluating how well Wavelet77 genes are linked to Juan GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet77	Juan GS	0.77	-1.02	-0.99	0.63	3.17
Juan GS	Wavelet77	0.75	-1.72	-0.54	0.34	7.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet77	Juan GS	0.00	-0.76	-1.45	0.84	0.53
Juan GS	Wavelet77	0.01	-1.24	-0.54	1.10	3.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wavelet77	77	76	KDR
Juan GS	12	12