Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Mu100 Exclusive	OldEA	2.59e-01	7.61e-01	2.21e-06	8.91e-06
OldEA Exclusive	Mu100	3.73e-06	8.20e-01	1.41e-08	1.88e-12
Mu100 Exclusive	OldEA Exclusive	1.51e-01	7.01e-01	5.74e-06	3.74e-05
OldEA Exclusive	Mu100 Exclusive	7.87e-07	8.45e-01	8.43e-08	8.72e-12
Mu100 Exclusive	Overlap	3.51e-01	7.27e-01	1.15e-02	2.55e-02
OldEA Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	5.36e-04	8.03e-03	7.54e-45	1.18e-32



Evaluating how well Mu100 genes are linked to OldEA genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Mu100 Exclusive	OldEA	0.75	-1.34	0.47	0.99	5.28
OldEA Exclusive	Mu100	0.71	-1.72	-0.52	0.60	9.68
Mu100 Exclusive	OldEA Exclusive	0.74	-1.46	0.55	1.15	4.37
OldEA Exclusive	Mu100 Exclusive	0.70	-2.26	-0.69	0.27	10.42
Mu100 Exclusive	Overlap	0.92	-2.39	-0.04	1.04	2.16
OldEA Exclusive	Overlap	1.00	1.57	2.32	2.01	2.31
Overlap	Exclusives	0.78	1.87	3.75	1.40	12.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Mu100 Exclusive	OldEA	0.00	-1.41	-0.12	0.99	2.39
OldEA Exclusive	Mu100	0.02	-0.46	0.29	3.30	14.16
Mu100 Exclusive	OldEA Exclusive	0.00	-1.26	0.12	1.29	3.77
OldEA Exclusive	Mu100 Exclusive	0.02	-0.89	-0.62	1.97	7.66
Mu100 Exclusive	Overlap	0.00	-1.11	-0.54	0.82	0.61
OldEA Exclusive	Overlap	0.04	21.77	145.72	120.33	329.30
Overlap	Exclusives	0.04	7.25	12.78	4.39	34.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Mu100 Exclusive	149	148	
OldEA Exclusive	27	27	
Overlap	2	2