Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OldEA Exclusive	GS29	9.09e-01	3.89e-01	2.54e-08	2.01e-07
GS29 Exclusive	OldEA	6.53e-05	5.57e-01	2.38e-06	2.18e-10
OldEA Exclusive	GS29 Exclusive	8.45e-01	2.68e-01	4.59e-08	1.61e-06
GS29 Exclusive	OldEA Exclusive	4.43e-05	4.66e-01	2.41e-07	4.99e-10
OldEA Exclusive	Overlap	5.90e-01	4.91e-01	9.92e-02	1.33e-01
GS29 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	1.54e-05	7.91e-04	2.43e-42	1.09e-24



Evaluating how well OldEA genes are linked to GS29 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OldEA Exclusive	GS29	0.78	-0.17	1.53	1.76	6.19
GS29 Exclusive	OldEA	0.68	-1.58	0.24	0.46	8.07
OldEA Exclusive	GS29 Exclusive	0.78	-0.19	1.86	1.61	5.28
GS29 Exclusive	OldEA Exclusive	0.68	-1.80	0.32	0.94	7.35
OldEA Exclusive	Overlap	0.95	-1.23	0.62	1.02	1.47
GS29 Exclusive	Overlap	1.00	1.32	4.46	1.57	1.85
Overlap	Exclusives	0.75	1.82	3.52	1.74	11.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OldEA Exclusive	GS29	0.00	-1.16	-0.69	1.81	5.64
GS29 Exclusive	OldEA	0.02	-0.61	0.48	2.50	8.13
OldEA Exclusive	GS29 Exclusive	0.00	-1.18	-0.71	1.29	3.40
GS29 Exclusive	OldEA Exclusive	0.01	-0.87	0.22	3.26	6.68
OldEA Exclusive	Overlap	0.00	-0.85	-0.14	0.17	0.73
GS29 Exclusive	Overlap	0.02	16.27	511.50	98.58	138.27
Overlap	Exclusives	0.03	6.92	10.17	4.44	30.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OldEA Exclusive	151	149	;SPANXB1
GS29 Exclusive	28	28	
Overlap	1	1