Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Consensus2_MS Exclusive	All_IMSGC	1.16e-04	1.83e-05	1.08e-09	4.60e-09
All_IMSGC Exclusive	Consensus2_MS	7.68e-02	1.21e-02	3.29e-04	1.30e-04
Consensus2_MS Exclusive	All_IMSGC Exclusive	1.77e-04	4.03e-05	4.08e-09	9.15e-09
All_IMSGC Exclusive	Consensus2_MS Exclusive	7.85e-02	1.27e-02	5.73e-04	1.64e-04
Consensus2_MS Exclusive	Overlap	3.21e-01	3.12e-01	1.43e-01	1.19e-01
All_IMSGC Exclusive	Overlap	5.40e-01	5.40e-01	5.40e-01	5.79e-01
Overlap	Exclusives	3.60e-04	7.13e-06	1.22e-40	8.15e-15



Evaluating how well Consensus2_MS genes are linked to All_IMSGC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Consensus2_MS Exclusive	All_IMSGC	0.59	3.45	5.65	3.51	7.42
All_IMSGC Exclusive	Consensus2_MS	0.59	3.44	3.08	3.33	3.83
Consensus2_MS Exclusive	All_IMSGC Exclusive	0.59	3.30	5.22	3.55	7.26
All_IMSGC Exclusive	Consensus2_MS Exclusive	0.59	4.04	3.18	2.86	3.03
Consensus2_MS Exclusive	Overlap	0.87	1.26	1.31	1.50	1.81
All_IMSGC Exclusive	Overlap	0.72	0.40	0.46	0.28	1.01
Overlap	Exclusives	0.60	2.28	7.34	2.55	8.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Consensus2_MS Exclusive	All_IMSGC	0.04	4.49	6.39	4.86	8.46
All_IMSGC Exclusive	Consensus2_MS	0.01	5.01	0.97	5.42	4.52
Consensus2_MS Exclusive	All_IMSGC Exclusive	0.04	3.86	5.68	4.34	8.26
All_IMSGC Exclusive	Consensus2_MS Exclusive	0.01	3.81	1.15	4.20	3.96
Consensus2_MS Exclusive	Overlap	0.00	0.39	0.22	1.29	1.00
All_IMSGC Exclusive	Overlap	0.00	7.83	6.60	3.10	2.00
Overlap	Exclusives	0.05	2.60	7.61	2.82	9.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Consensus2_MS Exclusive	134	131	AL669918.1;CCDC169-SOHLH2;Consensus2
All_IMSGC Exclusive	558	527	;LOC152225;LINC01100;1-Sep;GATA3-AS1;MIR4778;MIR21;MIR548AN;PVT1;ZEB1-AS1;CTB-50L17.10;PCAT1;MIR1208;LINC00977;All (IMSGC);SSTR5-AS1;1-Mar;LOC285626;RPL34-AS1;LOC285740;MIR4262;LOC100506746;LINC01082;U47924.1;SNORA66;LOC646626;JAZF1-AS1;RP11-345J4.5;ST13P4;MYO15B;9-Mar
Overlap	2	2