Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML Exclusive	OT_300	4.52e-03	1.21e-05	1.32e-01	5.33e-11
OT_300 Exclusive	EAML	4.37e-02	7.16e-02	1.42e-03	1.47e-01
EAML Exclusive	OT_300 Exclusive	7.02e-03	3.81e-05	2.30e-01	1.48e-10
OT_300 Exclusive	EAML Exclusive	1.39e-01	1.03e-01	8.17e-03	3.29e-01
EAML Exclusive	Overlap	2.69e-03	1.38e-03	6.02e-03	3.70e-03
OT_300 Exclusive	Overlap	1.38e-03	1.63e-02	1.38e-03	1.60e-03
Overlap	Exclusives	3.14e-05	5.36e-11	2.19e-30	6.71e-20



Evaluating how well EAML genes are linked to OT_300 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML Exclusive	OT_300	0.70	1.88	5.38	1.45	7.42
OT_300 Exclusive	EAML	0.54	4.25	2.22	2.02	1.25
EAML Exclusive	OT_300 Exclusive	0.70	1.72	6.09	1.38	8.32
OT_300 Exclusive	EAML Exclusive	0.52	4.20	1.77	1.39	0.87
EAML Exclusive	Overlap	0.97	2.74	4.08	2.81	3.08
OT_300 Exclusive	Overlap	0.99	3.40	3.26	3.06	2.94
Overlap	Exclusives	0.71	1.43	8.37	2.07	11.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML Exclusive	OT_300	0.01	3.32	9.36	2.15	6.48
OT_300 Exclusive	EAML	0.01	15.29	1.62	1.42	1.53
EAML Exclusive	OT_300 Exclusive	0.01	2.66	7.10	2.08	5.04
OT_300 Exclusive	EAML Exclusive	0.01	10.90	0.74	0.33	1.46
EAML Exclusive	Overlap	0.00	12.63	41.98	5.09	3.83
OT_300 Exclusive	Overlap	0.01	13.56	1.11	23.02	31.77
Overlap	Exclusives	0.04	4.81	23.17	7.29	37.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML Exclusive	76	76	
OT_300 Exclusive	127	125	GUCY1B2;TUBB3
Overlap	3	3