Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
huri	gwas1	1.70e-01	4.09e-01	2.15e-01	9.41e-01
gwas1	huri	3.77e-01	4.47e-01	1.21e-01	2.80e-01



Evaluating how well huri genes are linked to gwas1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
huri	gwas1	0.51	-1.39	-1.59	-1.25	0.23
gwas1	huri	0.47	-0.51	-0.68	-0.76	-0.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
huri	gwas1	0.00	-0.54	-0.88	-0.61	-0.29
gwas1	huri	0.00	-0.80	-0.41	-0.93	-1.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
huri	77	77	
gwas1	25	24	HLA -DRB1