Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
huri	clinvar	9.78e-01	8.52e-01	9.41e-01	3.32e-02
clinvar	huri	9.19e-01	2.29e-01	1.48e-03	2.13e-01



Evaluating how well huri genes are linked to clinvar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
huri	clinvar	0.66	0.26	0.74	0.21	2.72
clinvar	huri	0.53	1.67	1.36	1.64	1.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
huri	clinvar	0.00	-0.27	0.34	-0.36	0.79
clinvar	huri	0.00	-0.00	0.27	0.20	0.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
huri	77	77	
clinvar	21	21