Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
strex	ctd	5.83e-02	1.17e-01	1.19e-01	2.18e-05
ctd	strex	1.77e-03	1.14e-01	8.79e-02	2.80e-03



Evaluating how well strex genes are linked to ctd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
strex	ctd	0.65	-1.67	-1.71	-0.38	5.31
ctd	strex	0.58	-1.99	-1.30	-1.00	2.48

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
strex	ctd	0.01	-1.56	-2.05	-0.66	2.74
ctd	strex	0.00	-1.71	-1.72	-1.13	0.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
strex	73	71	CMKBR6;NELFE
ctd	103	89	MIR375;MIR505;SNAR-I;ATP7;MIR708;MIR146A;MIR100;MIR3622B;MIR4467;MIR296;CTR1B;CTR1C;MIR124A-3;MIR766