Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
strex	gwas1	5.88e-01	7.69e-01	7.14e-01	2.13e-01
gwas1	strex	1.39e-01	7.18e-01	5.58e-01	1.31e-02



Evaluating how well strex genes are linked to gwas1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
strex	gwas1	0.56	-0.81	-0.59	-0.43	1.08
gwas1	strex	0.59	-1.05	-0.47	-0.68	2.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
strex	gwas1	0.00	-0.76	-0.73	-0.59	0.08
gwas1	strex	0.00	-1.00	-0.94	-0.41	0.97

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
strex	73	71	CMKBR6;NELFE
gwas1	25	24	HLA -DRB1