Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
7GeneClusterConsen Exclusive	BRCA-Familial	1.85e-14	7.79e-12	5.76e-19	1.12e-18
BRCA-Familial Exclusive	7GeneClusterConsen	6.59e-11	2.25e-08	2.29e-67	3.42e-28
7GeneClusterConsen Exclusive	BRCA-Familial Exclusive	1.04e-03	4.03e-04	1.05e-07	2.07e-07
BRCA-Familial Exclusive	7GeneClusterConsen Exclusive	4.40e-08	2.56e-06	8.82e-67	2.52e-26
7GeneClusterConsen Exclusive	Overlap	1.71e-12	4.84e-10	2.90e-14	7.98e-14
BRCA-Familial Exclusive	Overlap	2.08e-13	1.03e-13	2.66e-14	7.98e-14
Overlap	Exclusives	4.65e-18	6.04e-12	3.90e-27	3.65e-26



Evaluating how well 7GeneClusterConsen genes are linked to BRCA-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
7GeneClusterConsen Exclusive	BRCA-Familial	0.99	3.72	7.32	3.62	7.75
BRCA-Familial Exclusive	7GeneClusterConsen	0.69	2.78	5.38	2.16	11.96
7GeneClusterConsen Exclusive	BRCA-Familial Exclusive	0.98	3.02	3.26	3.01	3.98
BRCA-Familial Exclusive	7GeneClusterConsen Exclusive	0.67	2.58	4.86	1.71	11.28
7GeneClusterConsen Exclusive	Overlap	1.00	3.88	6.59	3.34	6.16
BRCA-Familial Exclusive	Overlap	1.00	2.66	6.50	2.84	7.85
Overlap	Exclusives	0.69	2.24	6.93	2.89	15.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
7GeneClusterConsen Exclusive	BRCA-Familial	0.25	13.75	136.62	24.77	216.73
BRCA-Familial Exclusive	7GeneClusterConsen	0.10	7.14	51.55	19.31	70.75
7GeneClusterConsen Exclusive	BRCA-Familial Exclusive	0.01	0.42	8.68	6.82	52.56
BRCA-Familial Exclusive	7GeneClusterConsen Exclusive	0.07	7.76	29.49	9.80	40.60
7GeneClusterConsen Exclusive	Overlap	0.33	16.09	167.00	23.75	955.65
BRCA-Familial Exclusive	Overlap	0.29	39.43	460.37	282.45	169.20
Overlap	Exclusives	0.10	12.50	54.19	23.05	78.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
7GeneClusterConsen Exclusive	425	423	;PRAMEF11
BRCA-Familial Exclusive	8	8	
Overlap	15	15