Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
7GeneClusterConsen Exclusive	BRCA-GWAS	2.22e-02	4.87e-01	4.39e-09	4.87e-07
BRCA-GWAS Exclusive	7GeneClusterConsen	2.36e-02	2.46e-01	1.17e-16	7.47e-18
7GeneClusterConsen Exclusive	BRCA-GWAS Exclusive	1.34e-02	7.37e-01	7.68e-08	8.73e-05
BRCA-GWAS Exclusive	7GeneClusterConsen Exclusive	2.18e-02	4.02e-01	3.78e-18	5.98e-17
7GeneClusterConsen Exclusive	Overlap	1.73e-02	8.53e-02	4.83e-04	4.25e-06
BRCA-GWAS Exclusive	Overlap	7.71e-03	5.50e-02	3.24e-05	8.41e-07
Overlap	Exclusives	1.08e-11	2.82e-11	9.67e-63	5.87e-30



Evaluating how well 7GeneClusterConsen genes are linked to BRCA-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
7GeneClusterConsen Exclusive	BRCA-GWAS	0.63	-0.82	0.74	1.22	5.19
BRCA-GWAS Exclusive	7GeneClusterConsen	0.64	-0.17	1.36	1.13	11.01
7GeneClusterConsen Exclusive	BRCA-GWAS Exclusive	0.61	-1.04	0.14	0.58	5.41
BRCA-GWAS Exclusive	7GeneClusterConsen Exclusive	0.63	-0.17	0.78	1.48	10.67
7GeneClusterConsen Exclusive	Overlap	0.92	2.13	2.92	2.29	5.14
BRCA-GWAS Exclusive	Overlap	0.94	2.46	2.78	2.97	5.40
Overlap	Exclusives	0.68	3.19	8.09	3.31	15.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
7GeneClusterConsen Exclusive	BRCA-GWAS	0.02	-1.03	5.79	2.55	14.74
BRCA-GWAS Exclusive	7GeneClusterConsen	0.04	0.60	4.38	3.64	19.21
7GeneClusterConsen Exclusive	BRCA-GWAS Exclusive	0.01	-3.42	0.31	-0.16	7.15
BRCA-GWAS Exclusive	7GeneClusterConsen Exclusive	0.04	0.28	3.23	3.23	19.32
7GeneClusterConsen Exclusive	Overlap	0.07	19.23	90.50	42.42	119.70
BRCA-GWAS Exclusive	Overlap	0.02	2.60	2.70	14.93	31.91
Overlap	Exclusives	0.09	8.58	31.08	16.32	48.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
7GeneClusterConsen Exclusive	429	427	;PRAMEF11
BRCA-GWAS Exclusive	162	162	
Overlap	11	11