Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
7GeneClusterConsen Exclusive	BRCA-Somatic	5.31e-02	1.01e-01	1.19e-07	1.03e-16
BRCA-Somatic Exclusive	7GeneClusterConsen	1.42e-04	2.58e-01	4.46e-27	1.36e-15
7GeneClusterConsen Exclusive	BRCA-Somatic Exclusive	5.26e-01	7.10e-01	6.12e-06	7.19e-12
BRCA-Somatic Exclusive	7GeneClusterConsen Exclusive	1.74e-04	3.16e-01	1.16e-25	1.77e-15
7GeneClusterConsen Exclusive	Overlap	2.18e-03	2.77e-02	2.99e-07	3.36e-08
BRCA-Somatic Exclusive	Overlap	6.07e-09	7.83e-07	5.33e-09	9.38e-09
Overlap	Exclusives	1.18e-21	5.39e-15	1.75e-99	7.71e-41



Evaluating how well 7GeneClusterConsen genes are linked to BRCA-Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
7GeneClusterConsen Exclusive	BRCA-Somatic	0.91	-0.22	3.03	1.53	8.85
BRCA-Somatic Exclusive	7GeneClusterConsen	0.64	0.05	2.73	1.35	11.32
7GeneClusterConsen Exclusive	BRCA-Somatic Exclusive	0.88	-0.37	1.70	1.41	8.12
BRCA-Somatic Exclusive	7GeneClusterConsen Exclusive	0.63	0.14	1.99	1.17	10.88
7GeneClusterConsen Exclusive	Overlap	0.98	1.00	2.66	1.63	5.41
BRCA-Somatic Exclusive	Overlap	0.99	1.69	3.36	2.75	5.31
Overlap	Exclusives	0.71	3.75	9.19	2.99	14.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
7GeneClusterConsen Exclusive	BRCA-Somatic	0.03	-2.66	14.39	0.23	7.09
BRCA-Somatic Exclusive	7GeneClusterConsen	0.04	-0.40	4.54	3.40	18.26
7GeneClusterConsen Exclusive	BRCA-Somatic Exclusive	0.01	-1.98	1.04	-0.97	10.76
BRCA-Somatic Exclusive	7GeneClusterConsen Exclusive	0.04	-0.51	2.25	2.43	11.77
7GeneClusterConsen Exclusive	Overlap	0.07	-0.04	37.90	3.12	267.77
BRCA-Somatic Exclusive	Overlap	0.03	0.76	41.77	45.37	20.04
Overlap	Exclusives	0.09	8.76	39.56	15.33	61.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
7GeneClusterConsen Exclusive	431	429	;PRAMEF11
BRCA-Somatic Exclusive	28	28	
Overlap	9	9