Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MS_Consensus2 Exclusive	IMSGC_2019	1.28e-06	7.11e-06	2.69e-09	2.25e-11
IMSGC_2019 Exclusive	MS_Consensus2	2.76e-03	1.71e-02	7.18e-05	3.57e-04
MS_Consensus2 Exclusive	IMSGC_2019 Exclusive	1.29e-05	3.99e-05	3.19e-08	9.68e-11
IMSGC_2019 Exclusive	MS_Consensus2 Exclusive	2.68e-02	5.86e-02	1.22e-03	1.57e-03
MS_Consensus2 Exclusive	Overlap	2.10e-05	2.40e-05	2.19e-05	2.88e-05
IMSGC_2019 Exclusive	Overlap	1.30e-03	2.23e-03	1.30e-03	1.94e-03
Overlap	Exclusives	9.15e-14	6.69e-23	2.03e-21	7.07e-30



Evaluating how well MS_Consensus2 genes are linked to IMSGC_2019 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_Consensus2 Exclusive	IMSGC_2019	0.65	2.83	6.07	3.04	8.40
IMSGC_2019 Exclusive	MS_Consensus2	0.61	3.92	4.22	3.67	4.10
MS_Consensus2 Exclusive	IMSGC_2019 Exclusive	0.64	3.24	5.60	2.90	7.58
IMSGC_2019 Exclusive	MS_Consensus2 Exclusive	0.60	3.29	3.90	3.08	4.38
MS_Consensus2 Exclusive	Overlap	0.99	3.71	4.40	3.71	4.08
IMSGC_2019 Exclusive	Overlap	0.89	3.48	3.37	2.66	3.26
Overlap	Exclusives	0.68	2.96	12.45	3.41	14.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MS_Consensus2 Exclusive	IMSGC_2019	0.03	6.18	16.02	6.49	13.89
IMSGC_2019 Exclusive	MS_Consensus2	0.01	7.44	7.82	7.28	7.27
MS_Consensus2 Exclusive	IMSGC_2019 Exclusive	0.02	6.55	12.31	5.40	9.03
IMSGC_2019 Exclusive	MS_Consensus2 Exclusive	0.01	3.29	3.43	2.20	4.45
MS_Consensus2 Exclusive	Overlap	0.03	110.43	62.45	72.06	4.87
IMSGC_2019 Exclusive	Overlap	0.02	42.38	3.24	38.98	53.93
Overlap	Exclusives	0.06	8.41	41.96	9.59	32.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MS_Consensus2 Exclusive	133	131	AL669918.1;CCDC169-SOHLH2
IMSGC_2019 Exclusive	280	238	FGFR3P1;PVT1;SATB1-AS1;LINC01146;LOC100505625;MIR1208;LINC01108;CASC19;MTCO3P1;MIR100HG;LINC00824;MIR4778;LOC100129203;LINC01082;PRNCR1;LINC00271;LOC101060498;MIR548AN;IL12A-AS1;LOC285740;ZDHHC20P2;LINC00603;LOC102723854;LOC101929282;MIR1204;HLA-DPB2;ZEB1-AS1;LPP-AS2;LOC102467146;GABARAPL3;ZNF767P;LOC100506457;CD27-AS1;MIR4435-1HG;LOC152225;LOC285626;LOC100130476;LOC102724874;IMSGC,2019;SSTR5-AS1;LOC100129603;LOC102723649
Overlap	5	5