Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
plamalogengenes	EAML	1.95e-03	6.63e-01	7.00e-03	1.66e-01
EAML	plamalogengenes	5.06e-01	5.79e-01	6.62e-01	3.59e-01



Evaluating how well plamalogengenes genes are linked to EAML genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
plamalogengenes	EAML	0.53	-0.84	-0.44	-0.71	1.46
EAML	plamalogengenes	0.50	-0.23	-0.35	-0.32	-0.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
plamalogengenes	EAML	0.01	-0.84	-0.53	-0.57	0.69
EAML	plamalogengenes	0.00	-0.44	-0.50	-0.36	-0.40

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
plamalogengenes	9	9	
EAML	206	205