Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Consensus2 Exclusive	OMIM_Mala_Clin	2.30e-02	1.05e-02	1.10e-02	5.34e-04
OMIM_Mala_Clin Exclusive	Consensus2	2.34e-02	5.90e-02	5.68e-09	1.04e-02
Consensus2 Exclusive	OMIM_Mala_Clin Exclusive	9.69e-02	5.68e-02	5.04e-02	2.06e-03
OMIM_Mala_Clin Exclusive	Consensus2 Exclusive	3.75e-02	8.83e-02	2.64e-07	2.15e-02
Consensus2 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
OMIM_Mala_Clin Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	1.95e-06	1.68e-06	3.50e-14	3.17e-07



Evaluating how well Consensus2 genes are linked to OMIM_Mala_Clin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Consensus2 Exclusive	OMIM_Mala_Clin	0.84	1.55	2.42	1.70	4.14
OMIM_Mala_Clin Exclusive	Consensus2	0.57	2.48	2.37	1.49	2.84
Consensus2 Exclusive	OMIM_Mala_Clin Exclusive	0.82	1.64	2.10	1.36	3.18
OMIM_Mala_Clin Exclusive	Consensus2 Exclusive	0.56	2.43	2.30	1.17	2.53
Consensus2 Exclusive	Overlap	1.00	1.68	1.56	1.44	1.96
OMIM_Mala_Clin Exclusive	Overlap	1.00	2.55	1.85	1.89	1.65
Overlap	Exclusives	0.63	3.13	5.04	3.32	5.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Consensus2 Exclusive	OMIM_Mala_Clin	0.01	17.76	38.39	15.17	9.67
OMIM_Mala_Clin Exclusive	Consensus2	0.01	7.03	3.59	2.97	3.71
Consensus2 Exclusive	OMIM_Mala_Clin Exclusive	0.00	5.99	15.76	6.08	4.07
OMIM_Mala_Clin Exclusive	Consensus2 Exclusive	0.01	5.52	3.28	2.89	2.57
Consensus2 Exclusive	Overlap	0.02	87.43	106.23	56.45	83.24
OMIM_Mala_Clin Exclusive	Overlap	0.02	121.85	9.16	48.42	101.55
Overlap	Exclusives	0.02	9.71	15.75	9.16	20.45

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Consensus2 Exclusive	134	132	CCDC169-SOHLH2;AL669918.1
OMIM_Mala_Clin Exclusive	9	8	CCR5AS
Overlap	1	1