Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_ADSP-5K_new	AD_GS_13	1.55e-01	3.74e-02	3.26e-01	8.10e-03
AD_GS_13	EAML_ADSP-5K_new	5.08e-02	1.84e-02	1.38e-08	1.71e-01



Evaluating how well EAML_ADSP-5K_new genes are linked to AD_GS_13 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_ADSP-5K_new	AD_GS_13	0.76	1.93	3.00	0.92	3.57
AD_GS_13	EAML_ADSP-5K_new	0.55	4.53	3.03	2.54	1.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_ADSP-5K_new	AD_GS_13	0.00	2.96	2.14	0.80	4.59
AD_GS_13	EAML_ADSP-5K_new	0.01	4.20	1.65	1.87	0.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_ADSP-5K_new	106	101	;RFPL2;AL162417.1;PRAMEF11;TNFSF12-TNFSF13
AD_GS_13	14	14