Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_ADSP-5K_new Exclusive	AD_GS_25	1.48e-03	3.04e-04	3.36e-03	3.82e-05
AD_GS_25 Exclusive	EAML_ADSP-5K_new	2.95e-01	3.83e-02	1.37e-03	2.99e-01
EAML_ADSP-5K_new Exclusive	AD_GS_25 Exclusive	2.03e-03	8.65e-04	6.90e-03	4.85e-04
AD_GS_25 Exclusive	EAML_ADSP-5K_new Exclusive	2.68e-01	5.65e-02	2.72e-03	3.75e-01
EAML_ADSP-5K_new Exclusive	Overlap	1.23e-01	5.40e-01	2.04e-01	2.80e-02
AD_GS_25 Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
Overlap	Exclusives	9.10e-04	1.61e-04	1.11e-28	3.03e-04



Evaluating how well EAML_ADSP-5K_new genes are linked to AD_GS_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_ADSP-5K_new Exclusive	AD_GS_25	0.78	2.65	4.77	2.32	4.62
AD_GS_25 Exclusive	EAML_ADSP-5K_new	0.55	2.42	2.71	2.43	1.60
EAML_ADSP-5K_new Exclusive	AD_GS_25 Exclusive	0.76	3.27	4.71	2.19	4.23
AD_GS_25 Exclusive	EAML_ADSP-5K_new Exclusive	0.54	2.92	2.20	2.19	1.17
EAML_ADSP-5K_new Exclusive	Overlap	0.94	2.48	1.26	1.49	2.34
AD_GS_25 Exclusive	Overlap	1.00	2.56	2.37	2.89	2.51
Overlap	Exclusives	0.60	3.98	6.18	2.42	4.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_ADSP-5K_new Exclusive	AD_GS_25	0.00	4.39	4.52	2.51	3.99
AD_GS_25 Exclusive	EAML_ADSP-5K_new	0.01	4.96	7.93	5.47	2.96
EAML_ADSP-5K_new Exclusive	AD_GS_25 Exclusive	0.00	5.44	1.99	1.18	6.59
AD_GS_25 Exclusive	EAML_ADSP-5K_new Exclusive	0.01	1.74	4.88	2.22	1.46
EAML_ADSP-5K_new Exclusive	Overlap	0.00	4.66	3.81	2.12	6.34
AD_GS_25 Exclusive	Overlap	0.04	95.00	195.49	89.24	27.02
Overlap	Exclusives	0.05	111.55	104.18	31.01	75.21

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_ADSP-5K_new Exclusive	104	99	;AL162417.1;RFPL2;PRAMEF11;TNFSF12-TNFSF13
AD_GS_25 Exclusive	23	22	HLA -DRB1
Overlap	2	2