Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
5K_old	14GS	9.63e-05	3.28e-06	5.49e-04	9.33e-07
14GS	5K_old	5.15e-01	4.27e-01	9.09e-06	5.87e-01



Evaluating how well 5K_old genes are linked to 14GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
5K_old	14GS	0.85	2.51	4.81	2.32	4.34
14GS	5K_old	0.50	2.42	0.83	0.98	0.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
5K_old	14GS	0.00	5.18	11.83	4.09	6.68
14GS	5K_old	0.01	3.84	4.31	2.78	1.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
5K_old	98	98	
14GS	14	14