Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
25GS Exclusive	14GS	3.20e-08	7.24e-09	2.54e-09	5.49e-09
14GS Exclusive	25GS	9.53e-11	2.59e-10	2.48e-12	3.18e-12
25GS Exclusive	14GS Exclusive	5.50e-08	1.15e-08	4.89e-09	6.76e-09
14GS Exclusive	25GS Exclusive	4.32e-10	1.41e-09	6.27e-12	2.49e-11
25GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
14GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	3.41e-16	2.97e-17	1.49e-20	1.04e-18



Evaluating how well 25GS genes are linked to 14GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
25GS Exclusive	14GS	0.97	4.65	6.95	3.60	5.71
14GS Exclusive	25GS	0.92	4.66	8.11	4.65	7.09
25GS Exclusive	14GS Exclusive	0.96	4.48	6.57	3.62	5.95
14GS Exclusive	25GS Exclusive	0.91	5.40	7.27	4.22	7.16
25GS Exclusive	Overlap	1.00	1.22	1.62	1.98	1.75
14GS Exclusive	Overlap	1.00	2.36	1.79	2.01	1.49
Overlap	Exclusives	0.92	2.00	9.43	2.60	8.78

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
25GS Exclusive	14GS	0.04	34.71	37.51	60.66	5.27
14GS Exclusive	25GS	0.03	12.07	79.50	20.54	70.64
25GS Exclusive	14GS Exclusive	0.04	45.56	25.88	52.82	99.56
14GS Exclusive	25GS Exclusive	0.02	13.43	51.61	23.10	45.43
25GS Exclusive	Overlap	0.01	8.52	5.27	21.57	12.99
14GS Exclusive	Overlap	0.02	120.86	138.37	40.41	41.88
Overlap	Exclusives	0.02	10.64	48.73	6.23	8.05

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
25GS Exclusive	24	23	HLA -DRB1
14GS Exclusive	13	13	
Overlap	1	1