Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2020 10K removed-67	14GS	2.24e-01	2.09e-01	1.93e-01	1.37e-03
14GS	2020 10K removed-67	5.23e-01	7.10e-02	8.63e-08	3.06e-02



Evaluating how well 2020 10K removed-67 genes are linked to 14GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2020 10K removed-67	14GS	0.76	1.25	1.54	0.94	3.23
14GS	2020 10K removed-67	0.57	2.56	3.09	2.38	2.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2020 10K removed-67	14GS	0.00	0.42	-0.15	0.10	1.54
14GS	2020 10K removed-67	0.01	1.85	1.59	1.46	1.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2020 10K removed-67	108	106	TNFSF12-TNFSF13;RFPL2
14GS	14	14