Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2020_10K_removed-6 Exclusive	25GS	8.70e-01	6.37e-01	9.14e-01	3.77e-02
25GS Exclusive	2020_10K_removed-6	9.19e-01	2.24e-01	8.92e-02	1.14e-01
2020_10K_removed-6 Exclusive	25GS Exclusive	8.79e-01	7.37e-01	8.19e-01	5.19e-02
25GS Exclusive	2020_10K_removed-6 Exclusive	7.59e-01	2.15e-01	9.87e-02	1.84e-01
2020_10K_removed-6 Exclusive	Overlap	7.92e-01	5.40e-01	7.79e-01	8.69e-02
25GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	6.93e-02	1.50e-03	1.09e-25	2.14e-03



Evaluating how well 2020_10K_removed-6 genes are linked to 25GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2020_10K_removed-6 Exclusive	25GS	0.64	0.37	0.62	0.32	2.35
25GS Exclusive	2020_10K_removed-6	0.55	1.49	2.05	1.52	2.13
2020_10K_removed-6 Exclusive	25GS Exclusive	0.62	0.66	0.54	0.38	2.12
25GS Exclusive	2020_10K_removed-6 Exclusive	0.55	1.32	1.60	1.31	1.73
2020_10K_removed-6 Exclusive	Overlap	0.87	1.00	0.13	0.80	1.88
25GS Exclusive	Overlap	1.00	2.56	2.12	2.91	2.68
Overlap	Exclusives	0.61	2.28	4.46	2.83	4.41

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2020_10K_removed-6 Exclusive	25GS	0.00	-0.24	-0.39	-0.30	-0.03
25GS Exclusive	2020_10K_removed-6	0.01	1.81	0.47	0.98	2.23
2020_10K_removed-6 Exclusive	25GS Exclusive	0.00	-0.15	-0.12	-0.31	0.26
25GS Exclusive	2020_10K_removed-6 Exclusive	0.01	0.01	0.13	0.20	0.15
2020_10K_removed-6 Exclusive	Overlap	0.00	-0.01	-3.47	0.11	0.43
25GS Exclusive	Overlap	0.04	54.71	180.37	225.43	65.83
Overlap	Exclusives	0.04	53.93	50.72	27.20	33.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2020_10K_removed-6 Exclusive	106	104	TNFSF12-TNFSF13;RFPL2
25GS Exclusive	23	22	HLA -DRB1
Overlap	2	2