Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_NewLabels_10K_UKBAC1 Exclusive	AD-Familial	2.58e-04	2.19e-06	3.03e-09	3.91e-08
AD-Familial Exclusive	ADSP_NewLabels_10K_UKBAC1	4.29e-03	2.07e-01	9.14e-10	3.86e-08
ADSP_NewLabels_10K_UKBAC1 Exclusive	AD-Familial Exclusive	1.48e-02	2.08e-04	1.14e-06	1.22e-06
AD-Familial Exclusive	ADSP_NewLabels_10K_UKBAC1 Exclusive	2.96e-02	5.05e-01	8.27e-09	6.92e-08
ADSP_NewLabels_10K_UKBAC1 Exclusive	Overlap	1.45e-03	2.13e-03	1.38e-03	2.03e-03
AD-Familial Exclusive	Overlap	1.38e-03	1.38e-03	1.38e-03	1.45e-03
Overlap	Exclusives	4.09e-04	3.25e-03	1.49e-13	4.12e-11



Evaluating how well ADSP_NewLabels_10K_UKBAC1 genes are linked to AD-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_NewLabels_10K_UKBAC1 Exclusive	AD-Familial	0.93	2.76	5.26	2.98	5.36
AD-Familial Exclusive	ADSP_NewLabels_10K_UKBAC1	0.67	1.88	1.39	0.81	6.13
ADSP_NewLabels_10K_UKBAC1 Exclusive	AD-Familial Exclusive	0.92	2.45	3.78	2.62	5.02
AD-Familial Exclusive	ADSP_NewLabels_10K_UKBAC1 Exclusive	0.66	1.32	0.75	0.53	5.48
ADSP_NewLabels_10K_UKBAC1 Exclusive	Overlap	0.96	1.83	3.05	2.29	2.72
AD-Familial Exclusive	Overlap	1.00	6.88	3.06	3.18	3.20
Overlap	Exclusives	0.70	1.20	2.85	0.78	8.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_NewLabels_10K_UKBAC1 Exclusive	AD-Familial	0.01	-0.03	16.35	5.13	10.33
AD-Familial Exclusive	ADSP_NewLabels_10K_UKBAC1	0.03	20.41	25.34	15.40	47.57
ADSP_NewLabels_10K_UKBAC1 Exclusive	AD-Familial Exclusive	0.00	-0.07	9.34	3.35	1.84
AD-Familial Exclusive	ADSP_NewLabels_10K_UKBAC1 Exclusive	0.02	5.92	6.66	5.45	9.88
ADSP_NewLabels_10K_UKBAC1 Exclusive	Overlap	0.00	0.84	10.55	2.48	0.45
AD-Familial Exclusive	Overlap	0.36	761.27	1621.84	396.98	154.21
Overlap	Exclusives	0.03	9.99	22.05	7.59	25.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_NewLabels_10K_UKBAC1 Exclusive	111	111	
AD-Familial Exclusive	11	11	
Overlap	3	3