Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_NewLabels_5K_UKBAC1 Exclusive	AD-Familial	6.01e-04	5.30e-09	1.21e-08	2.08e-08
AD-Familial Exclusive	ADSP_NewLabels_5K_UKBAC1	6.38e-04	8.01e-02	4.92e-04	6.46e-04
ADSP_NewLabels_5K_UKBAC1 Exclusive	AD-Familial Exclusive	6.96e-03	3.27e-07	1.78e-07	3.39e-07
AD-Familial Exclusive	ADSP_NewLabels_5K_UKBAC1 Exclusive	4.14e-03	1.97e-01	3.24e-03	4.34e-03
ADSP_NewLabels_5K_UKBAC1 Exclusive	Overlap	2.80e-02	1.65e-02	1.65e-02	2.43e-02
AD-Familial Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	2.93e-06	3.76e-06	2.98e-10	4.93e-07



Evaluating how well ADSP_NewLabels_5K_UKBAC1 genes are linked to AD-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_NewLabels_5K_UKBAC1 Exclusive	AD-Familial	0.92	2.28	6.00	2.97	4.80
AD-Familial Exclusive	ADSP_NewLabels_5K_UKBAC1	0.69	2.16	1.50	0.75	4.47
ADSP_NewLabels_5K_UKBAC1 Exclusive	AD-Familial Exclusive	0.92	2.19	5.39	3.38	5.01
AD-Familial Exclusive	ADSP_NewLabels_5K_UKBAC1 Exclusive	0.67	1.61	1.12	0.48	3.94
ADSP_NewLabels_5K_UKBAC1 Exclusive	Overlap	0.95	1.22	2.78	1.81	2.21
AD-Familial Exclusive	Overlap	1.00	5.89	2.22	2.60	2.25
Overlap	Exclusives	0.75	1.90	4.46	1.36	5.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_NewLabels_5K_UKBAC1 Exclusive	AD-Familial	0.00	1.07	13.70	4.28	11.37
AD-Familial Exclusive	ADSP_NewLabels_5K_UKBAC1	0.02	34.13	21.41	13.00	28.20
ADSP_NewLabels_5K_UKBAC1 Exclusive	AD-Familial Exclusive	0.00	0.43	13.09	4.84	8.62
AD-Familial Exclusive	ADSP_NewLabels_5K_UKBAC1 Exclusive	0.01	7.18	4.28	3.90	9.78
ADSP_NewLabels_5K_UKBAC1 Exclusive	Overlap	0.00	-0.03	2.30	0.78	1.27
AD-Familial Exclusive	Overlap	0.20	678.34	1060.67	566.81	710.70
Overlap	Exclusives	0.03	16.42	56.05	12.10	44.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_NewLabels_5K_UKBAC1 Exclusive	38	38	
AD-Familial Exclusive	12	12	
Overlap	2	2