Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_NewLabels_10K_UKBAC1_controls	AD-Familial	7.48e-01	2.31e-02	3.62e-02	1.73e-03
AD-Familial	ADSP_NewLabels_10K_UKBAC1_controls	6.71e-01	9.67e-01	9.42e-05	2.69e-04



Evaluating how well ADSP_NewLabels_10K_UKBAC1_controls genes are linked to AD-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_NewLabels_10K_UKBAC1_controls	AD-Familial	0.76	0.71	2.82	1.46	3.22
AD-Familial	ADSP_NewLabels_10K_UKBAC1_controls	0.62	1.62	0.49	0.41	3.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_NewLabels_10K_UKBAC1_controls	AD-Familial	0.00	-0.46	0.70	0.81	1.24
AD-Familial	ADSP_NewLabels_10K_UKBAC1_controls	0.01	1.04	0.11	0.21	2.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_NewLabels_10K_UKBAC1_controls	73	73	
AD-Familial	14	14